I'm going to try to avoid telling you "self-help bullshit" that'll only make this metaphor even more obnoxious, but I sympathize with that constant feeling that no achievement will ever lead to personal satisfaction. Hell, I won a world title and that didn't cure me of my desire to constantly strive for significance - it just gave me a biochemical brain high that lasted longer than normal. In theory, personal satisfaction is independent from anything you "do", but I'm still struggling to find it's true source. I can't speak for everyone either, but philosophy, meditation, talk therapy, and medication are the things that have helped my mental health the most, not achievement or overcoming struggle.